Preheat the oven to 375 degrees. For easier cleanup, line a rimmed baking sheet with aluminum foil. Place a wire rack in the baking sheet (optional).
Twist each slice of bacon very tightly then place on the wire rack, if using. If you aren't using a rack, place on the foil-lined baking sheet with the pieces touching so they don't untwist.
Place into the oven to bake for 20 minutes. Flip over and bake for another 20 minutes, or until crispy-soft and cooked through.
Remove from the oven and transfer to a paper towel to drain. Serve and enjoy.
Side Note: Store any leftover twisted bacon in an airtight container for 3 days.